Madagascar split from Africa so long ago that most of its wildlife evolved alone. Lemurs, many chameleons, strange spiny forests and six of the world's baobab species exist here and almost nowhere else. The indri's dawn song in Andasibe, one of the loudest calls of any lemur, is the sound people remember.
The island is huge and the roads are slow, so we plan it as a journey rather than a tour: the rainforest of the east, the highlands and Ranomafana, then south to the canyons of Isalo, with a few flights to cut out the longest drives. A beach on Île Sainte-Marie or Nosy Be finishes it off.
Be ready for the trade-offs. Lodges are comfortable but simpler than on the other islands, drives can take all day, and domestic flights change at short notice, so we build in slack. Healthcare outside the capital is limited.