Antarctica has no hotels, no airports for visitors and no country to arrive in. Almost every trip is an expedition voyage, and most leave from Ushuaia at the southern tip of Argentina. You cross the Drake Passage in about two days, then spend five or so days among the islands and channels of the Antarctic Peninsula.
Each day brings one or two landings by inflatable boat, at penguin colonies, whaling relics and old research huts, and cruises among icebergs where seals haul out on the floes. Expedition staff choose sites around the weather and the ice, so no two voyages are the same.
The honest trade-off is the Drake. It can be calm or it can be rough for two days each way. Longer voyages add the Falklands and South Georgia; fly-cruise options skip one crossing but depend on weather at the airstrip.